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A histone methyltransferase inhibitor can reverse epigenetically acquired drug resistance in the malaria parasite <i>Plasmodium falciparum</i>

2019-09-19

Abstract excerpt

Malaria parasites invade and replicate within red blood cells (RBCs), extensively modifying their structure and gaining access to the extracellular environment by placing the plasmodial surface anion channel (PSAC) into the RBC membrane. Expression of members of the cytoadherence linked antigen gene 3 ( clag3 ) family is required for PSAC activity, a process that is regulated epigenetically. PSAC is a well-establ...

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Literature Corpus work
c8f3442f-2f45-53e3-8473-c12052c37597
DOI
10.1101/775734
Open publication

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