Article

Engineering of human brain organoids with a functional vascular-like system

2019-10-07

Abstract excerpt

<title>Abstract</title> <p>Here, we engineered human embryonic stem cells (hESCs) to ectopically express human ETS variant 2 (ETV2) to create in vitro vasculature in cortical organoids (hCOs), namely vhCOs (vascularized hCOs). ETV2-expressing cells in hCOs contributed to forming a complex vascular-like network in hCOs. This protocol describes hESC maintenance, the generation of inducible ETV2 expressing hESCs, an...

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Literature Corpus work: c8e87601-1ca8-5e7d-9ac9-001a1fd1e3c7
DOI: 10.21203/rs.2.13464/v1

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