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Article

Ferroptosis in Liver Diseases: An Overview

11 Jul 2020

Abstract excerpt

Ferroptosis is an iron-dependent form of cell death characterized by intracellular lipid peroxide accumulation and redox imbalance. Ferroptosis shows specific biological and morphological features when compared to the other cell death patterns. The loss of lipid peroxide repair activity by glutathione peroxidase 4 (GPX4), the presence of redox-active iron and the oxidation of polyunsaturated fatty acid...

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PMID: 32664576
DOI: 10.3390/ijms21144908

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