Article

Novel LHX8 variants associated with distinctive oocyte morphological abnormalities and maturation arrest in primary infertility

2025-10-20

Abstract excerpt

<title>Abstract</title> <p> Background <italic>LHX8</italic> gene encodes a germ cell specific transcription factor that is required for oocyte development. We evaluated two unrelated women with primary infertility who showed reproducible oocyte abnormalities across in vitro fertilization cycles, and we performed genomic and functional assays to clarify the role of <italic>LHX8</italic> . Results Whole exome...

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Literature Corpus work: c8caff3f-f164-51a9-974a-d3de1fff61c2
DOI: 10.21203/rs.3.rs-7460153/v1

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