Article

A tripartite structure, the complex nuclear receptor element (cNRE), is a <i>c</i> is-regulatory module of viral origin required for atrial chamber preferential gene expression

2021-11-20

Abstract excerpt

Optimal cardiac function requires appropriate contractile proteins in each heart chamber. Atria require slow myosins to act as variable reservoirs, while ventricles demand fast myosin for swift pumping functions. Hence, myosin is under chamber-biased cis -regulatory control to achieve this functional distribution. Failure in proper regulation of myosin genes can lead to severe congenital heart dysfunction. The pr...

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Literature Corpus work: c893415a-3f9e-57bf-881d-cdb6eef225f0
DOI: 10.1101/2021.11.18.469087

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