Article

Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial chamber

2023-08-21

Abstract excerpt

<title>Abstract</title> Optimal cardiac function requires appropriate contractile proteins in each heart chamber. Atria require slow myosins to act as variable reservoirs, while ventricles demand fast myosin for swift pumping functions. To achieve this functional distribution, myosins are thus under chamber-biased <italic>cis</italic>-regulatory control, with a failure in proper regulation of myosin genes lead...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8233bb3f-c8d9-5e22-95b8-3a7d96e647b0
DOI: 10.21203/rs.3.rs-3207862/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial chamberDOI 10.21203/rs.3.rs-3207862/v1Read

A tripartite structure, the complex nuclear receptor element (cNRE), is a c is-regulatory module of viral origin required for atrial chamber preferential gene expressionSemantic proximity Read

Genome-wide Computational Analysis Reveals Cardiomyocyte-specific Transcriptional Cis-regulatory Motifs That Enable Efficient Cardiac Gene TherapySemantic proximity Read

In Vivo Dissection of Chamber-Selective Enhancers Reveals Estrogen-Related Receptor as a Regulator of Ventricular Cardiomyocyte IdentitySemantic proximity Read

Irx4 Forms an Inhibitory Complex with the Vitamin D and Retinoic X Receptors to Regulate Cardiac Chamber-specific slow MyHC3ExpressionSemantic proximity Read

Transcription factors and the cardiac gene programme.Semantic proximity Read

Reengineering Inducible Cardiac-Specific Transgenesis With an Attenuated Myosin Heavy Chain PromoterSemantic proximity Read

Translational control of furina by an RNA regulon is essential for heart morphogenesis and cardiac valve functionSemantic proximity Read

Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo.Semantic proximity Read

Control of cardiac myosin heavy chain gene expressionSemantic proximity Read

Genetic excision of the regulatory cardiac troponin I extension in high–heart rate mammal cladesSemantic proximity Read

Genetic excision of the regulatory cardiac troponin I extension in high heart rate mammal cladesSemantic proximity Read

Transgenic analysis of the atrialnatriuretic factor (ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF.Semantic proximity Read