Article

Viral protease-Initiated Pyroptosis Activator mRNA therapy as a Universal Antiviral Strategy

2025-11-15

Abstract excerpt

Although therapeutic drugs targeting gasdermin (GSDM)-mediated pyroptosis have made remarkable progress in treating various diseases, their potential for antiviral therapy remains largely unexplored. Inspired by the autoinhibitory mechanism of GSDM proteins and the clinical success of mRNA vaccines, herein we propose a concept of viral protease-initiated pyroptosis (VIP) mRNA therapy as a universal antiviral strat...

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Identifiers and source

Literature Corpus work: c8358c34-e57d-53c0-a65c-dcaa32dd0abb
DOI: 10.1101/2025.11.14.688189

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