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Druggable genome screens identify SPP as an antiviral host target for multiple flaviviruses

19 Feb 2025

Abstract excerpt

Mosquito-borne flaviviruses, such as dengue virus (DENV), Zika virus (ZIKV), West Nile virus, and yellow fever virus, pose significant public health threats globally. Extensive efforts have led to the development of promising highly active compounds against DENV targeting viral non-structural protein 4B (NS4B) protein. However, due to the cocirculation of flaviviruses and to prepare for emerging flaviviruses,...

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PMID: 39969998
DOI: 10.1073/pnas.2421573122

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