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Article

Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus

1 Sept 2019

Abstract excerpt

Background Flaviviruses such as Zika cause sporadic pandemic outbreaks worldwide. There is an urgent need for anti-Zika virus (ZIKV) drugs to prevent mother-to-child transmission of ZIKV, new infections in high-risk populations, and the infection of medical personnel in ZIKV-affected areas. Methods Here, we showed that the small molecule 6-deoxyglucose-diphyllin (DGP) exhibited anti-ZIKV activity both in vitro...

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PMID: 31501074
DOI: 10.1016/j.ebiom.2019.08.060

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