Article
Genetic variants with small discordant effects on eGFR and risk of CKD
2026-08-01
Abstract excerpt
CKD is defined by sustained reductions in eGFR and the presence of albuminuria. A single eGFR assessment—derived from creatinine or cystatin C—fail to capture glomerular hyperfiltration, a state where increased clearance per nephron imposes mechanical or metabolic stress. Because we lack reliable methods to estimate nephron number or mass, the essential denominator to determine single-nephron GFR, hyperfiltration...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- c7d3cf65-e5ad-5855-9d3c-6c054a83eb1d
- DOI
- 10.1016/j.ekir.2026.107011