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petVAE: A Data-Driven Model for Identifying Amyloid PET Subgroups Across the Alzheimer’s Disease Continuum

2026-02-04

Abstract excerpt

Amyloid-β (Aβ) PET imaging is a core biomarker and is sufficient for the biological diagnosis of Alzheimer’s disease (AD). Here, we aimed to identify biologically meaningful subgroups across the continuum of Aβ accumulation using a data-driven deep learning approach, without imposing predefined thresholds for Aβ negativity or positivity. We analyzed 3,110 Aβ PET scans from the Alzheimer’s Disease Neuroimaging Init...

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Literature Corpus work: c73a5f38-c28b-56ce-9d4a-d265e66d9e78
DOI: 10.64898/2026.02.02.703218

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