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Evaluation of Deep Learning Algorithms to Predict Multiple Dementia-Related Neuropathologies from Brain MRI, Clinical and Genetic Data

2025-09-01

Abstract excerpt

Alzheimer’s disease and related dementias (ADRD) involve overlapping neurodegenerative and vascular pathologies—such as amyloid-β (Aβ), tau, cerebral amyloid angiopathy (CAA), TDP-43, and alpha-synuclein—that complicate diagnosis and treatment. While PET and CSF biomarkers are useful for detecting Aβ and tau, they are invasive, expensive, and not widely available. In contrast, magnetic resonance imaging (MRI) is n...

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Literature Corpus work: b3c41b8d-fbdd-56b3-a009-f3ac9a6bcdca
DOI: 10.1101/2025.08.27.672683

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