Article

Genetic Profiling in Heterogeneous High-Grade Adenoid Cystic Carcinoma Identifies NOTCH1 Inhibition as a Therapeutic Strategy

2020-12-10

Abstract excerpt

<title>Abstract</title> <p>BackgroundHigh-grade adenoid cystic carcinomas (ACCs), consisting mostly of the solid type along with the occasional high-grade transformation (ACC-HGT) type, are highly aggressive and heterogeneous tumors. Because of the rarity of the tumors, therapeutic strategy guided by genetic profiles based on next generation sequencing (NGS) has been not published on these tumors. MethodsForty-fo...

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Literature Corpus work: a877e109-3d5c-534d-b00e-b6b14733db18
DOI: 10.21203/rs.3.rs-120255/v1

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