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De novo subtype and strain identification of botulinum neurotoxin type B through toxin proteomics

6 Mar 2012

Abstract excerpt

Botulinum neurotoxins (BoNTs) cause the disease botulism, which can be lethal if untreated. There are seven known serotypes of BoNT, A-G, defined by their response to antisera. Many serotypes are distinguished into differing subtypes based on amino acid sequence, and many subtypes are further differentiated into toxin variants. Previous work in our laboratory described the use of a proteomics approach to...

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PMID: 22395449
DOI: 10.1007/s00216-012-5767-3

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