Article

Enformer-Based Phylogenetic Tree Reconstruction

2026-06-06

Abstract excerpt

Enformer is a deep learning model trained on human and mouse genomes to predict regulatory activity from 196,608 bp DNA windows. Its trunk embeddings capture long-range cis-regulatory interactions, but whether this signal generalises across the tree of life has not been assessed. We embed universal single-copy orthologous groups (OGs) from OrthoDB v12 across three taxonomic scales and evaluate reconstructed trees...

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Literature Corpus work: c5d7ea55-2dac-5f4d-8cde-6e9227c76253
DOI: 10.64898/2026.06.05.730316

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