Article

Mapping bias overestimates reference allele frequencies at the <i>HLA</i> genes in the 1000 Genomes Project phase I data

2014-12-23

Abstract excerpt

Next Generation Sequencing (NGS) technologies have become the standard for data generation in studies of population genomics, as the 1000 Genomes Project (1000G). However, these techniques are known to be problematic when applied to highly polymorphic genomic regions, such as the Human Leukocyte Antigen ( HLA ) genes. Because accurate genotype calls and allele frequency estimations are crucial to population ge-no...

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Literature Corpus work: c5cc3940-1ff7-58a9-a2fb-f972e4af5bea
DOI: 10.1101/013151

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