Article

Trauma Exposure, PTSD, and Methylation of the Blood Brain Barrier Claudin-5 Gene

2025-11-25

Abstract excerpt

Posttraumatic stress disorder (PTSD) is associated with early onset of neurological conditions, but the mechanism by which PTSD relates to diseases of the central nervous system is unclear. One possibility is that PTSD perpetuates breakdown of the blood brain barrier (BBB), allowing for bidirectional passage of molecules across the periphery and central nervous system that promote neuropathology. Preclinical studi...

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Literature Corpus work: c5a1f334-bae6-5ae6-8893-6c558f0a60c2
DOI: 10.1101/2025.11.24.25340875

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