Article

T Cell Responses Induced by SARS-CoV-2 mRNA Vaccination Are Associated With Clonal Replacement

2022-10-18

Abstract excerpt

mRNA vaccines against the Spike glycoprotein of severe acute respiratory syndrome type 2 coronavirus (SARS-CoV-2) elicit strong T-cell responses. However, it is unknown whether T cell clones induced by the first vaccination or newly generated T cell clones dominate responses to the secondary vaccination. Here, we analyzed the kinetic profile of Spike-reactive T-cell clones before the first dose, one week after the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c58a72e7-499b-557e-b80d-a08d28615370
DOI: 10.2139/ssrn.4232457

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

T Cell Responses Induced by SARS-CoV-2 mRNA Vaccination Are Associated With Clonal ReplacementDOI 10.2139/ssrn.4232457Read

CD8+ T cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by shifts in clonal dominanceSemantic proximity Read

Rapid and stable mobilization of fully functional spike-specific CD8+ T cells preceding a mature humoral response after SARS-CoV-2 mRNA vaccinationSemantic proximity Read

Early CD4+ T cell responses induced by the BNT162b2 SARS-CoV-2 mRNA vaccine predict immunological memorySemantic proximity Read

Omicron Reactive Multi Protein Specific CD4 T Cells Defines Cellular Immune Response Induced by Inactivated Virus VaccinesSemantic proximity Read

Single cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccineSemantic proximity Read

CD8+ T cell clonotypes from prior SARS-CoV-2 infection predominate during the cellular immune response to mRNA vaccinationSemantic proximity Read

Single-cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccineSemantic proximity Read

mRNA Vaccine-Induced SARS-CoV-2 Spike-Specific IFN-γ and IL-2 T-cell Responses are Predictive of Serological Neutralization and are Transiently Enhanced by Pre-Existing Cross-Reactive ImmunitySemantic proximity Read

A comparative characterization of SARS-CoV-2-specific T cells induced by mRNA or inactive virus COVID-19 vaccinesSemantic proximity Read

SARS-CoV-2 vaccination diversifies the CD4+ spike-reactive T cell repertoire in patients with prior SARS-CoV-2 infectionSemantic proximity Read

SARS-CoV-2-Specific CD8<sup>+</sup> T Cells in Blood but Not in the Lungs of Vaccinated K18-hACE2 Mice after InfectionSemantic proximity Read

Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccineSemantic proximity Read