Article

Metabolic Reprogramming in Rheumatoid Arthritis Synovial Fibroblasts: a Hybrid Modeling Approach

2022-07-21

Abstract excerpt

Rheumatoid Arthritis (RA) is an autoimmune disease characterized by a highly invasive pannus formation consisting mainly of synovial fibroblasts (RASFs). This pannus leads to cartilage, bone and soft tissue destruction in the affected joint. RASFs’ activation is associated with metabolic alterations resulting from dysregulation of extracellular signals transduction and gene regulation machinery. Deciphering the in...

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Literature Corpus work: 26ffa73f-4202-5aef-be39-6f90d9141c67
DOI: 10.1101/2022.07.20.500752

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