Article

2,4-dinitrophenol downregulates genes for diabetes and fatty liver in obese mice

2015-07-13

Abstract excerpt

Whether obesity is a disease or a risk factor of chronic diseases including diabetes and fatty liver remains debating. We report here that a high-fat diet (HFD) alone or HFD and intramuscular injection of mice with a high dose (1.2 mg/kg) of lipopolysaccharide (LPS) induces the peripheral noninflammatory obesity. In contrast, HFD and intraperitoneal injection of mice with a low dose (0.25 mg/kg) of LPS induces the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c5781aab-3d6f-52fc-b5d5-c1a5b9aa0595
DOI: 10.7287/peerj.preprints.1229v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

2,4-dinitrophenol downregulates genes for diabetes and fatty liver in obese miceDOI 10.7287/peerj.preprints.1229v1Read

Curcumin protects against bisphenol A -induced hepatic steatosis by modulating gut microbiota and liver fat synthesis in CD-1 miceSemantic proximity Read

Liver immune responses to inflammatory stimuli in a diet-induced obesity model of zebrafishSemantic proximity Read

Effects of Nutritionally Induced Obesity on Metabolic Pathways of ZebrafishSemantic proximity Read

Non-alcoholic Fatty Liver Disease Induced by Perinatal Exposure to Bisphenol a Is Associated With Activated mTOR and TLR4/NF-κB Signaling Pathways in Offspring RatsSemantic proximity Read

“Regulation of Obesity and Fatty Liver by Moringa oleifera: Insights into Inflammatory Pathways”Semantic proximity Read

Clusterin overexpression protects against western diet-induced obesity and NAFLD.Semantic proximity Read

Cyclodipeptides Reversed Liver Damage and Adipose Tissue Dysfunction in a Chronic Obesity MASLD Rat Model by Remodeling White Adipocytes Toward a Beige-like Adipocyte Phenotype.Semantic proximity Read

A combination of CLA-DAG oil modifies the diabetic phenotype in male Zucker diabetic fatty rats.Semantic proximity Read

Perinatal exposure to bisphenol A exacerbates nonalcoholic steatohepatitis-like phenotype in male rat offspring fed on a high-fat diet.Semantic proximity Read

A Low Dose of Dietary Quercetin Fails to Protect against the Development of an Obese Phenotype in Mice.Semantic proximity Read

The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice.Semantic proximity Read

Nidogen 2 Overexpression Promotes Hepatosteatosis and AtherosclerosisSemantic proximity Read