Article

Leveraging Hardy–Weinberg disequilibrium for association testing in case-control studies

2020-11-16

Abstract excerpt

In a case-control association study, deviation from Hardy-Weinberg equilibrium (HWE) or Hardy-Weinberg dis-equilibrium (HWD) in the control group is usually considered as evidence for potential genotyping error, and the corresponding SNP is then removed from the study. On the other hand, assuming HWE holds in the study population, a truly associated SNP is expected to be out of HWE in the case group. Efforts have...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c5762c25-2e14-57d3-82b9-a3a6617d4027
DOI: 10.1101/2020.11.14.382796

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leveraging Hardy–Weinberg disequilibrium for association testing in case-control studiesDOI 10.1101/2020.11.14.382796Read

A likelihood ratio test of population Hardy-Weinberg equilibrium for case-control studies.Semantic proximity Read

Testing Hardy-Weinberg disequilibrium using the generalized linear model.Semantic proximity Read

Exploiting Hardy-Weinberg equilibrium for efficient screening of single SNP associations from case-control studies.Semantic proximity Read

Robust, flexible, and scalable tests for Hardy-Weinberg equilibrium across diverse ancestries.Semantic proximity Read

Calculation and use of the Hardy-Weinberg model in association studies.Semantic proximity Read

Hardy-Weinberg Equilibrium in Meta-Analysis Studies and Large-Scale Genomic Sequencing Era.Semantic proximity Read

Regression modeling of allele frequencies and testing Hardy Weinberg Equilibrium.Semantic proximity Read

Examining the rare disease assumption used to justify HWE testing with control samples.Semantic proximity Read

Assessing departure from Hardy-Weinberg equilibrium in the presence of disease association.Semantic proximity Read

Invited commentary: Testing for Hardy-Weinberg disequilibrium using a genome single-nucleotide polymorphism scan based on cases only.Semantic proximity Read

Population admixture: detection by Hardy-Weinberg test and its quantitative effects on linkage-disequilibrium methods for localizing genes underlying complex traits.Semantic proximity Read

Using both cases and controls for testing hardy-weinberg proportions in a genetic association study.Semantic proximity Read