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Article

Predicting mutation outcome from early stochastic variation in genetic interaction partners.

Nature - 7 Dec 2011

Burga Alejandro, Casanueva M Olivia, Lehner Ben

Abstract excerpt

Many mutations, including those that cause disease, only have a detrimental effect in a subset of individuals. The reasons for this are usually unknown, but may include additional genetic variation and environmental risk factors. However, phenotypic discordance remains even in the absence of genetic variation, for example between monozygotic twins, and incomplete penetrance of mutations is frequent in isogenic...

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PMID: 22158248
DOI: 10.1038/nature10665

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