Heritable epigenetic changes are constrained by the dynamics of regulatory architectures

Abstract excerpt

<h4>ABSTRACT</h4> Interacting molecules create regulatory architectures that can persist despite turnover of molecules. Although epigenetic changes occur within the context of such architectures, there is limited understanding of how they can influence the heritability of changes. Here I develop criteria for the heritability of regulatory architectures and use quantitative simulations of interacting regulators pa...

Topics

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• DNA Methylation
• Epigenesis, Genetic
• Gene Regulatory Networks
• Genome
• Heredity
• Inheritance Patterns
• Models, Genetic
• Mutation

Identifiers and source

Literature Corpus work

35e92138-a455-5d5f-ab4c-aecff67f0a71

DOI

10.1101/2023.06.07.544138