Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling of a negative feedback mechanism explains antagonistic pleiotropy in reproduction in domesticated Caenorhabditis elegans strains.

PLoS genetics - 1 May 2017

Large Edward E, Padmanabhan Raghavendra, Watkins Kathie L, Campbell Richard F, Xu Wen, McGrath Patrick T

Abstract excerpt

Most biological traits and common diseases have a strong but complex genetic basis, controlled by large numbers of genetic variants with small contributions to a trait or disease risk. The effect-size of most genetic variants is not absolute and is instead dependent upon multiple factors such as the age and genetic background of an organism. In order to understand the mechanistic basis of these changes, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Feedback, Physiological

Share to Genetic Pleiotropy

Share to Gonads

Share to Oocytes

Share to Spermatozoa

Source

Open in PubMed Open full text

Identifiers

PMID: 28493873
DOI: 10.1371/journal.pgen.1006769
PMCID: PMC5444864

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling of a negative feedback mechanism explains antagonistic pleiotropy in reproduction in domesticated Caenorhabditis elegans strains.PMID 28493873Read ↗

Modeling of a negative feedback mechanism explains age-dependent genetic architecture in reproduction in domesticated <i>C. elegans</i> strainsSemantic proximity Read ↗

Selection on a Subunit of the NURF Chromatin Remodeler Modifies Life History Traits in a Domesticated Strain of Caenorhabditis elegans.Semantic proximity Read ↗

Polygenicity and Epistasis Underlie Fitness-Proximal Traits in the Caenorhabditis elegans Multiparental Experimental Evolution (CeMEE) Panel.Semantic proximity Read ↗

From QTL to gene: C. elegans facilitates discoveries of the genetic mechanisms underlying natural variation.Semantic proximity Read ↗

Gene expression variation across genetically identical individuals predicts reproductive traitsSemantic proximity Read ↗

Testing life-history pleiotropy in Caenorhabditis elegans.Semantic proximity Read ↗

The effect of developmental variation on expression QTLs in a multi parental Caenorhabditis elegans population.Semantic proximity Read ↗

Genetic basis of offspring number-body weight tradeoff in Drosophila melanogaster.Semantic proximity Read ↗

Caenorhabditis elegans as a platform for molecular quantitative genetics and the systems biology of natural variation.Semantic proximity Read ↗

Maternal age generates phenotypic variation in Caenorhabditis elegans.Semantic proximity Read ↗

Many transcription factors contribute to C. elegans growth and fat storage.Semantic proximity Read ↗

Sexual and temporal dynamics of molecular evolution in C. elegans development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.