Article
A zebrafish model for <i>Mycobacterium leprae</i> granulomatous infection
2017-04-17
Abstract excerpt
Understanding the pathogenesis of leprosy granulomas has been hindered by a paucity of tractable experimental animal models. Mycobacterium leprae , which causes leprosy, grows optimally at ~30°C, so we sought to model granulomatous disease in the ectothermic zebrafish. We find noncaseating granulomas develop rapidly, and eventually eradicate infection. rag1 mutant zebrafish, which lack lymphocytes, also form non...
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Identifiers and source
- Literature Corpus work
- c55d6444-5311-5486-8b4d-ee203ce4ec8b
- DOI
- 10.1101/127639