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Article

A zebrafish model for ocular tuberculosis

27 Mar 2018

Abstract excerpt

Ocular tuberculosis (TB) commonly causes severe inflammation and vision loss in TB-endemic countries. The mechanism by which tuberculous infection becomes established in the eye is poorly understood. We have developed the zebrafish larva infected with Mycobacterium marinum as a model to study the early pathogenesis of ocular TB. We find that hematogenous bacterial seeding of the eye occurs despite a functional...

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PMID: 29584775
DOI: 10.1371/journal.pone.0194982

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