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Article

Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinant.

PLoS biology - 1 Nov 2004

Volkman Hannah E, Clay Hilary, Beery Dana, Chang Jennifer C W, Sherman David R, Ramakrishnan Lalita

Abstract excerpt

Granulomas are organized host immune structures composed of tightly interposed macrophages and other cells that form in response to a variety of persistent stimuli, both infectious and noninfectious. The tuberculous granuloma is essential for host containment of mycobacterial infection, although it does not always eradicate it. Therefore, it is considered a host-beneficial, if incompletely efficacious, immune...

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Identifiers

PMID: 15510227
DOI: 10.1371/journal.pbio.0020367
PMCID: PMC524251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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