Article

2-APB arrests human keratinocyte proliferation and inhibits cutaneous squamous cell carcinoma <i>in vitro</i>

2018-01-23

Abstract excerpt

<h4>Background</h4> The epidermis is a stratified epithelium whose differentiation program is triggered in part by calcium. Dysregulation of keratinocyte differentiation may lead to non-melanoma skin cancers, including cutaneous squamous cell carcinoma (cSCC). The compound 2-aminoethoxydiphenyl borate (2-APB) modulates calcium signaling by altering activity of calcium-permeable channels of the transient receptor...

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Literature Corpus work: c53159d9-bbf3-5c42-9bda-0e6856abe81d
DOI: 10.1101/249821

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