Article

Lineage origin and developmental context shape tumor states in MYCN-dependent zebrafish neuroblastoma

2025-10-14

Abstract excerpt

Neuroblastoma, a neural-crest-derived malignancy of the peripheral nervous system, is a devastating pediatric disease characterized by high intra- and intertumoral heterogeneity. While several tumor expression programs correlate with patient outcome, the developmental and contextual determinants of their emergence remain incompletely understood. Here, we systematically dissected neuroblastoma transcriptional heter...

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Literature Corpus work: c50d473d-57bb-56c9-b112-0a650689ed21
DOI: 10.1101/2025.10.13.682025

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