Article

Targeting p53 Dysfunction in Hepatocellular Carcinoma: Translational Barriers and Opportunities for AI-Driven Precision Medicine

2026-02-27

Abstract excerpt

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with TP53 dysfunction representing a central molecular alteration in approximately 30% of cases [1,2]. Despite robust preclinical evidence supporting p53 as a therapeutic target, clinical translation has been severely limited by delivery challenges, tumor heterogeneity, the cirrhotic microenvironment, and inadequate patie...

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Literature Corpus work: c5044a9e-b06e-57b0-9c8c-b6624baf249c
DOI: 10.20944/preprints202602.1888.v1

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