Article
The perplexity of targeting genetic alterations in hepatocellular carcinoma.
Medical oncology (Northwood, London, England) - 22 Jul 2020
Barone Michele, Di Leo Alfredo, Sabbà Carlo, Mazzocca Antonio
Abstract excerpt
Genetic heterogeneity is a well-recognized feature of hepatocellular carcinoma (HCC). The coexistence of multiple genetic alterations in the same HCC nodule contributes to explain why gene-targeted therapy has largely failed. Targeting of early genetic alterations could theoretically be a more effective therapeutic strategy preventing HCC. However, the failure of most targeted therapies has raised much perplexity...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.