Article

Early Reduction of SARS-CoV-2 Replication in Bronchial Epithelium by Kinin B<sub>2</sub> Receptor Antagonism

2021-08-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> SARS-CoV2 has evolved to enter the host via the ACE2 receptor which is part of the Kinin-kallirein pathway. This complex pathway is only poorly understood in context of immune regulation but critical to control infection. This study examines SARS-CoV2 infection and epithelial mechanisms of the kinin-kallikrein system at the kinin B 2 receptor level in SARS-CoV-2 infection that...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c4c1382d-d19a-5018-9fd6-41f8f9631174
DOI: 10.1101/2021.08.13.21262037

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early Reduction of SARS-CoV-2 Replication in Bronchial Epithelium by Kinin B<sub>2</sub> Receptor AntagonismDOI 10.1101/2021.08.13.21262037Read

SARS-CoV-2 receptor is co-expressed with elements of the kinin-kallikrein, renin-angiotensin and coagulation systems in alveolar cellsSemantic proximity Read

Expression of the SARS-CoV-2 <i>ACE2</i> Receptor in the Human Airway EpitheliumSemantic proximity Read

SARS-CoV-2 Omicron BA.2.86 & JN.1 shifting tropism from airway to intestineSemantic proximity Read

NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoidsSemantic proximity Read

SARS-CoV-2 infection suppresses ACE2 function and antiviral immune response in the upper respiratory tract of infected patientsSemantic proximity Read

The nasal symbiont Staphylococcus epidermidis shapes the cellular environment to decrease expression of SARS-CoV-2 entry factors in nasal epitheliumSemantic proximity Read

Expression of ACE2, TMPRSS2 and CTSL in human airway epithelial cells under physiological and pathological conditions: Implications for SARS-CoV-2 infectionSemantic proximity Read

SARS-CoV-2 strategically mimics proteolytic activation of human ENaCSemantic proximity Read

Expression Pattern of the SARS-CoV-2 Entry Genes ACE2 and TMPRSS2 in the Respiratory TractSemantic proximity Read

The Nasal Symbiont <i>Staphylococcus Epidermidis</i> Restricts the Transcription of SARS-CoV-2 Entry Factors in Human Nasal EpitheliumSemantic proximity Read

Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiologySemantic proximity Read

p53/NF-kB Balance in SARS-CoV-2 Infection: From OMICs, Genomics and Pharmacogenomics Insights to Tailored Therapeutic Perspectives (COVIDomics)Semantic proximity Read