Article

The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, non-toxic concentrations of interleukin 1 β

2019-08-30

Abstract excerpt

A central and still open question regarding the pathogenesis of autoimmune diseases, such as type 1 diabetes, concerns the processes that underlie the generation of MHC-presented autoantigenic epitopes that become targets of autoimmune attack. Proteasomal degradation is a key step in processing of proteins for MHC class I presentation. Different types of proteasomes can be expressed in cells dictating the repertoi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c461e2e1-2557-5467-8c42-897e770965d7
DOI: 10.1101/753061

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, non-toxic concentrations of interleukin 1 βDOI 10.1101/753061Read

Proteasome immunosubunits protect against the development of CD8 T cell-mediated autoimmune diseases.Semantic proximity Read

Mammalian proteasome subtypes: Their diversity in structure and function.Semantic proximity Read

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides.Semantic proximity Read

β2 Subunit Propeptides Influence Cooperative Proteasome AssemblySemantic proximity Read

The catalytic sites of 20S proteasomes and their role in subunit maturation: a mutational and crystallographic study.Semantic proximity Read

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.Semantic proximity Read

Quantitative analysis of prion-protein degradation by constitutive and immuno-20S proteasomes indicates differences correlated with disease susceptibility.Semantic proximity Read

The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner.Semantic proximity Read