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Article

Induction of Persistent Colitis by a Human Commensal, Enterotoxigenic<i>Bacteroides fragilis</i>, in Wild-Type C57BL/6 Mice

3 Feb 2009

Abstract excerpt

Enterotoxigenic Bacteroides fragilis (ETBF) causes diarrhea and is implicated in inflammatory bowel diseases and colorectal cancer. The only known ETBF virulence factor is the Bacteroides fragilis toxin (BFT), which induces E-cadherin cleavage, interleukin-8 secretion, and epithelial cell proliferation. A murine model for ETBF has not been characterized. Specific pathogen-free (SPF) C57BL/6J or germfree...

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PMID: 19188353
DOI: 10.1128/iai.00814-08

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