Article

Novel SLAMF1-derived peptide induces apoptosis in multiple myeloma cells by targeting IRF4 transcription factor for degradation

2025-05-10

Abstract excerpt

Multiple myeloma (MM) is the second most common hematological cancer. It remains incurable, highlighting the urgent need for novel therapeutic targets and treatment strategies. In this study, we investigated a panel of peptides derived from a functional motif of Signaling Lymphocytic Activation Molecule Family 1 (SLAMF1) with single amino acid substitutions and found that several of them exhibited potent anti-canc...

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Literature Corpus work: c3e3a28e-e90c-5e3a-887b-423471404f75
DOI: 10.1101/2025.05.07.652607

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