The Landscape of Signaling Pathways and Proteasome Inhibitors Combinations in Multiple Myeloma

doi:10.3390/cancers13061235

Article

The Landscape of Signaling Pathways and Proteasome Inhibitors Combinations in Multiple Myeloma

11 Mar 2021

Abstract excerpt

Multiple myeloma is a malignancy of terminally differentiated plasma cells, characterized by an extreme genetic heterogeneity that poses great challenges for its successful treatment. Due to antibody overproduction, MM cells depend on the precise regulation of the protein degradation systems. Despite the success of PIs in MM treatment, resistance and adverse toxic effects such as peripheral neuropathy and...

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