Article

Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum functions

2023-10-20

Abstract excerpt

GRP170, a product of the Hyou1 gene, is required for mouse embryonic development, and its ablation in kidney nephrons leads to renal failure. Unlike most chaperones, GRP170 is the lone member of its chaperone family in the ER lumen. However, the cellular requirement for GRP170, which both binds non-native proteins and acts as nucleotide exchange factor for BiP, is poorly understood. Here, we report on the isolati...

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Literature Corpus work: c3d2d77c-5450-5743-b960-6180607a839f
DOI: 10.1101/2023.10.19.563191

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