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Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function

6 Mar 2024

Abstract excerpt

GRP170 ( Hyou1) is required for mouse embryonic development, and its ablation in kidney nephrons leads to renal failure. Unlike most chaperones, GRP170 is the lone member of its chaperone family in the ER lumen. However, the cellular requirement for GRP170, which both binds nonnative proteins and acts as nucleotide exchange factor for BiP, is poorly understood. Here, we report on the isolation of mouse embryonic...

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PMID: 38446639
DOI: 10.1091/mbc.e24-01-0012

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