Back to search

Article

The SRC/NF-κB-AKT/NOS3 Axis as a Key Mediator of Kaempferol’s Protective Effects against Oxidative Stress-induced Osteoclastogenesis

2024-07-13

Abstract excerpt

Abstract: Osteoclasts are integral to the advancement of osteoporosis (OP), and their generation under conditions of oxidative stress (OS) involves various pathways. However, the specific mechanism through which the natural antioxidant kaempferol (KAE) mitigates the influence of OS on osteoclasts remains somewhat uncertain. In order to evaluate the effect of KAE on osteoclast formation under OS and explore its pos...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
af9a0a64-c5df-5197-8af6-8a35f6a0a75b
DOI
10.22541/au.172085362.24636492/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The SRC/NF-κB-AKT/NOS3 Axis as a Key Mediator of Kaempferol’s Protective Effects against Oxidative Stress-induced OsteoclastogenesisDOI 10.22541/au.172085362.24636492/v1
Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways.Semantic proximity
Potential Mechanisms Underlying Kaempferol-Promoted Osteoblast Proliferation and Osteogenic Differentiation: A Network Pharmacology and Experimental Validation StudySemantic proximity
IKK/NF‐κB and ROS signal axes are involved in Tenacissoside H mediated inhibitory effects on LPS‐induced inflammatory osteolysisSemantic proximity
Multi-layered Network Analysis of Osteoking in the Treatment of Osteoporosis: Unraveling Mechanisms from Gene Expression to Molecular DockingSemantic proximity
α-Mangostin Inhibits LPS-Induced Bone Resorption by Restricting Osteoclastogenesis Via NF-κB and MAPK SignalingSemantic proximity
Effect of wogonin, an active ingredient of Scutellariae Radix, on fish infected with Aeromonas hydrophilaSemantic proximity
Hyperoside Suppresses Osteoclasts Differentiation and Function through Down-Regulating TRAF6/p38 MAPK Signaling PathwaySemantic proximity
Multi-layered Network Analysis of Osteoking in the Treatment of Osteoporosis: Unraveling Mechanisms from Gene Expression to Molecular DockingSemantic proximity
Sesamolin Protects Mice From Ovariectomized Bone Loss by Inhibiting Osteoclastogenesis and RANKL-Mediated NF-κB and MAPK Signaling PathwaysSemantic proximity
Investigation of Anti-osteoporosis Mechanisms of Rehmanniae Radix Preparata Based on Network Pharmacology and Experimental VerificationSemantic proximity
Predicting and Exploring the Mechanisms of Erzhi Pill in Prevention and Treatment of Osteoporosis Based on Network Pharmacology and Zebrafish ExperimentsSemantic proximity
Safflower Yellow a Attenuates Osteoarthritis via Regulating Inflammation and Cholesterol MetabolismSemantic proximity
Select a neighboring publication to make it the new centre.