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Article

Disulfiram combined with copper inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma through the NF-κB and TGF-β pathways.

Journal of cellular and molecular medicine - 1 Jan 2018

Li Yi, Wang Li-Hui, Zhang Hao-Tian, Wang Ya-Ting, Liu Shuai, Zhou Wen-Long, Yuan Xiang-Zhong, Li Tian-Yang, Wu Chun-Fu, Yang Jing-Yu

Abstract excerpt

Late-stage hepatocellular carcinoma (HCC) usually has a low survival rate because of the high risk of metastases and the lack of an effective cure. Disulfiram (DSF) has copper (Cu)-dependent anticancer properties in vitro and in vivo. The present work aims to explore the anti-metastasis effects and molecular mechanisms of DSF/Cu on HCC cells both in vitro and in vivo. The results showed that DSF inhibited the...

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Identifiers

PMID: 29148232
DOI: 10.1111/jcmm.13334
PMCID: PMC5742719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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