Article

DNA binding is rate-limiting for natural transformation

2024-06-06

Abstract excerpt

Bacteria take up environmental DNA using dynamic appendages called type IV pili (T4P) to elicit horizontal gene transfer in a process called natural transformation. Natural transformation is widespread amongst bacteria yet determining how different factors universally contribute to or limit this process across species has remained challenging. Here we show that Acinetobacter baylyi , the most naturally transforma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c379a884-9cef-57a4-b198-78c55b72be18
DOI: 10.1101/2024.06.06.597730

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA binding is rate-limiting for natural transformationDOI 10.1101/2024.06.06.597730Read

The molecular basis for DNA-binding by competence T4P is distinct in Gram-positive and Gram-negative speciesSemantic proximity Read

Type 4 pili mediated natural competence in <i>Fusobacterium nucleatum</i>Semantic proximity Read

Bacterial transformation: distribution, shared mechanisms and divergent control.Semantic proximity Read

Type IV pilus biogenesis, twitching motility, and DNA uptake in Thermus thermophilus: discrete roles of antagonistic ATPases PilF, PilT1, and PilT2.Semantic proximity Read

Intragenomic conflicts with plasmids and chromosomal mobile genetic elements drive the evolution of natural transformation within speciesSemantic proximity Read

DNA uptake and twitching motility are controlled by the small RNA Arp through repression of pilin translation in <i>Acinetobacter baumannii</i>Semantic proximity Read

Complete functional analysis of type IV pilus components of a reemergent plant pathogen reveals neofunctionalization of paralog genesSemantic proximity Read

Competence for natural transformation in Neisseria gonorrhoeae: components of DNA binding and uptake linked to type IV pilus expression.Semantic proximity Read

Pili are essential for conjugation also in many Gram-positive bacteriaSemantic proximity Read

Bacterial transformation buffers environmental fluctuations through the reversible integration of mobile genetic elementsSemantic proximity Read

Transposon-insertion sequencing in a clinical isolate of <i>Legionella pneumophila</i> identifies essential genes and determinants of natural transformationSemantic proximity Read

Complete functional analysis of type IV pilus components of a reemergent plant pathogen reveals neofunctionalization of paralog genes.Semantic proximity Read