Article

Pili are essential for conjugation also in many Gram-positive bacteria

2025-12-18

Abstract excerpt

Type IV secretion systems (T4SS) enable the spread of antibiotic resistance and other virulence factors. In Gram-positive bacteria, T4SSs have long been thought to lack VirB2-like proteins that form conjugative pili and instead rely on adhesins for cell-cell contacts. Yet, it has remained unclear how subsequent DNA transfer (conjugation) is physically mediated. Here we identify a VirB2-like protein, PrgF B2 , fro...

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Literature Corpus work: 83d6424e-7a73-57ac-a026-0450e078802d
DOI: 10.64898/2025.12.18.695078

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