The molecular basis for DNA-binding by competence T4P is distinct in Gram-positive and Gram-negative species

Abstract excerpt

<h4>ABSTRACT</h4> Competence type IV pili (T4P) are bacterial surface appendages that facilitate DNA uptake during horizontal gene transfer by natural transformation. These dynamic structures actively extend from the cell surface, bind to DNA in the environment, and then retract to import bound DNA into the cell. Competence T4P are found in diverse Gram-negative (diderm) and Gram-positive (monoderm) bacterial spe...

Topics

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• Bacterial Infections and Vaccines
• Bacterial Proteins
• Gene Expression Regulation, Bacterial
• Genome, Bacterial
• Genome-Wide Association Study
• Lipid Membrane Structure and Behavior
• Mutation
• Streptococcal Infections and Treatments

Identifiers and source

Literature Corpus work

40bffb83-68c7-506e-9c68-8b6d359a00c4

DOI

10.1101/2025.02.17.638644