Article

SCDT: Detecting somatic CNVs of low chimeric ratio in cf-DNA

2018-09-07

Abstract excerpt

<h4>Motivation</h4> Sequencing of cell-free DNA (cf-DNA) has enabled Noninvasive Prenatal Testing (NIPT) and”liquid biopsy” of cancers. However, while the aneuploidy and point mutations were focused on by most of NITP and liquid biopsy studies, detecting sub-chromosome CNVs that affect a few to dozens of megabases was rarely reported, likely attributable to the difficulty in accurately identifying them, especiall...

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Literature Corpus work: fcfdad0d-086c-522b-a5e9-2728c1970fb3
DOI: 10.1101/411256

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