Article

Ultra-Content Screening (UCS): Toward the Big Blood Picture

2026-01-22

Abstract excerpt

We present Ultra-Content Screening (UCS), a novel, scalable method combining cyclic immunostaining with high-dimensional image-based single-cell proteomics. UCS utilizes fluorescein isothiocyanate-conjugated antibodies and iterative staining-photobleaching cycles to analyze up to 40 markers in up to 100,000 peripheral blood mononuclear cells per experiment. Through precise image registration, nuclear segmentation,...

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Literature Corpus work: c33aa58e-0c4c-5035-8de2-18b9c602d46c
DOI: 10.64898/2026.01.20.700546

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