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Tribus: semi-automated discovery of cell identities and phenotypes from multiplexed imaging and proteomic data.

Bioinformatics (Oxford, England) - 4 Mar 2025

Kang Ziqi, Szabo Angela, Farago Teodora, Perez-Villatoro Fernando, Junquera Ada, Shah Saundarya, Launonen Inga-Maria, Anttila Ella, Casado Julia, Elias Kevin, Virtanen Anni, Haltia Ulla-Maija, Färkkilä Anniina

Abstract excerpt

MOTIVATION: Multiplexed imaging and single-cell analysis are increasingly applied to investigate the tissue spatial ecosystems in cancer and other complex diseases. Accurate single-cell phenotyping based on marker combinations is a critical but challenging task due to (i) low reproducibility across experiments with manual thresholding, and, (ii) labor-intensive ground-truth expert annotation required for...

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Topics

Proteomics
Humans
Phenotype
Software
Single-Cell Analysis
Image Processing, Computer-Assisted

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Identifiers

PMID: 39982403
DOI: 10.1093/bioinformatics/btaf082
PMCID: PMC11932726

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