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Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections

27 Jan 2014

Abstract excerpt

The 2009 H1N1 pandemic and recent human cases of H5N1, H7N9, and H6N1 in Asia highlight the need for a universal influenza vaccine that can provide cross-strain or even cross-subtype protection. Here, we show that recombinant monoglycosylated hemagglutinin (HAmg) with an intact protein structure from either seasonal or pandemic H1N1 can be used as a vaccine for cross-strain protection against various H1N1 viruses...

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PMID: 24469815
DOI: 10.1073/pnas.1323954111

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