Article

G307S DNAM-1 mutation exacerbates autoimmune encephalomyelitis via enhancing CD4 <sup>+</sup> T cell activation

2022-06-10

Abstract excerpt

Although rs763361, which causes a non-synonymous glycine-to-serine mutation at residue 307 (G307S mutation) of the DNAM-1 immunoreceptor, is a single-nucleotide polymorphism (SNP) associated with autoimmune disease susceptibility, little is known about how the SNP is involved in pathogenesis. Here, we established CD4 + T cells expressing wild-type or G307S DNAM-1 and showed that the costimulatory signal from G307...

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Literature Corpus work: c24b183c-e251-5c1e-8b61-3feb6968e932
DOI: 10.1101/2022.06.08.495273

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