Article
Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients.
Genes and immunity - 1 Sept 2009
Wieczorek S, Hoffjan S, Chan A, Rey L, Harper L, Fricke H, Holle J U, Gross W L, Epplen J T, Lamprecht P
Abstract excerpt
Recently, there has been increasing evidence that a non-synonymous exchange (Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including type 1 diabetes, multiple sclerosis (MS), rheumatoid arthritis and Grave's disease. Here we present evidence that this polymorphism also predisposes to Wegener's granulomatosis (WG), an autoimmune condition belonging to the group of ANCA (antineutrophil...
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