Back to search

Article

“Differential Cortical Effects of Synaptic versus Extrasynaptic GABAA Receptor Modulation with Lorazepam and Brexanolone: A Randomized, Double-Blind, Placebo-Controlled, Cross-over TMS and EEG Trial.”

2026-08-21

Abstract excerpt

<b>Aims</b> GABAkines are a diverse class of compounds that modulate γ-aminobutyric acid (GABA) mediated inhibition, yet how their distinct receptor mechanisms translate into neurocircuit-level effects remains unclear. This study leveraged the benzodiazepine (BZD) lorazepam and neuroactive steroid (NAS) brexanolone to explore how synaptic versus combined synaptic and extrasynaptic GABA<sub>A</sub> receptor modulat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c22bd109-9c9e-58d0-8ebe-48e6f6c7caca
DOI
10.22541/authorea.15007748/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
“Differential Cortical Effects of Synaptic versus Extrasynaptic GABAA Receptor Modulation with Lorazepam and Brexanolone: A Randomized, Double-Blind, Placebo-Controlled, Cross-over TMS and EEG Trial.”DOI 10.22541/authorea.15007748/v1
Electroencephalographic Patterns Associated with the Pharmacokinetics and Pharmacodynamics of GABAergic Agents, Opioids, and Ketamine During General Anesthesia: A Narrative ReviewSemantic proximity
A high-resolution in vivo atlas of the human brain's benzodiazepine binding site of GABAA receptorsSemantic proximity
A High-Resolution In Vivo Atlas of the Human Brain’s Benzodiazepine Binding Site of GABA <sub>A</sub> ReceptorsSemantic proximity
General anesthesia dissociates discrete components of ketamine neurophysiologySemantic proximity
GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteers.Semantic proximity
Altered GABAergic Signaling in Brain Disease at Various Stages of LifeSemantic proximity
Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes.Semantic proximity
Systematic Evaluation of Adverse Drug Reactions Associated with Benzodiazepine Utilization: A Comprehensive ReviewSemantic proximity
The forgotten psychedelic: Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybinSemantic proximity
Pharmacological recruitment of a VTA glutamatergic arousal circuit by the natural product BN3 drives broad-spectrum emergence from general anesthesiaSemantic proximity
Uncovering putative neural mechanisms of neurotherapeutic impacts on EEG using the Human Neocortical NeurosolverSemantic proximity
Mechanistic simulation identifies predictive dose-dependent biomarkers of propofol anesthesiaSemantic proximity
Select a neighboring publication to make it the new centre.